Updated
Royal sun agaric
A Brazilian field mushroom that became a major supplement in Japan. It carries some of the few randomised oncology trials outside turkey tail.
Repeated trials
Where it stands: 5 registered trials in people, none of which has reported a result; 9 randomised trials published since 2007.
What it is taken for
One tile per use. The line under each is how far the evidence for that use actually got, counted rather than argued.
What it has been tried for, and how far that has got
One row per use. The label is counted rather than argued — it is set by how many randomised trials and posted results exist for that use, and nothing else. How that is worked out.
| Use | How far it has got | Trials | With a result | Randomised, published | Reviews | Commonly taken for it |
|---|---|---|---|---|---|---|
| Fatigue and energy | Repeated trials | 0 | 0 | 2 | 0 | — |
| Gut and microbiome | Repeated trials | 0 | 0 | 2 | 0 | — |
| Wound healing | Repeated trials | 0 | 0 | 2 | 0 | — |
| Blood sugar | A first trial | 1 | 0 | 1 | 0 | yes |
| Cancer, supportive and adjuvant | A first trial | 1 | 0 | 1 | 0 | yes |
| Liver | Being tested now | 1 | 0 | 0 | 0 | yes |
| Immune function | Laboratory work | 0 | 0 | 0 | 0 | yes |
Commonly taken for immune function. The work there is still laboratory and animal work — often a great deal of it — and the step into a trial in people has not been taken yet.
The doses the protocols actually specify
Taken verbatim from the intervention description each trial filed. These are not recommendations and they are not comparable to each other: some are a whole-mushroom powder, some a purified fraction.
| Dose as filed | Study | Condition | People |
|---|---|---|---|
60 ml | Agaricus Blazei Murill in Patients With Multiple Myeloma | Multiple Myeloma | 39 |
10 g | Effect of Agaricus Blazei (Murrill) ss. Heinemann (Sun Mushroom) | Hepatitis C, Nutritional Status | 10 |
20ml | Agaricus Blazei Murill (ABM) in Patients With Inflammatory Bowel Disease (IBD) | Inflammatory Bowel Disease | 20 |
30 ml | Anti-inflammatory Effect of Agaricus Blazei Murill in Inflammatory Bowel Disease | Ulcerative Colitis, Crohn's Disease | 100 |
Every registered study that names it
From ClinicalTrials.gov, filtered to studies that name Agaricus subrufescens or a synonym in the title, summary or intervention. Studies that have posted results come first.
| Register | Study | Condition | People | Status | Result posted | Dose in the protocol |
|---|---|---|---|---|---|---|
| NCT00970021 | Agaricus Blazei Murill in Patients With Multiple Myeloma | Multiple Myeloma | 39 | Completed | — | 60 ml |
| NCT00131287 | The Supplementary Effects of the Extract of Agaricus Blazei Murril on Type II Diabetes Mellitus (DM) | Diabetes Mellitus, Type II | 108 | Completed | — | — |
| NCT00564811 | Effect of Agaricus Blazei (Murrill) ss. Heinemann (Sun Mushroom) | Hepatitis C, Nutritional Status | 10 | Completed | — | 10 g |
| NCT01106742 | Agaricus Blazei Murill (ABM) in Patients With Inflammatory Bowel Disease (IBD) one ingredient in a multi-herb preparation | Inflammatory Bowel Disease | 20 | Completed | — | 20ml |
| NCT01496053 | Anti-inflammatory Effect of Agaricus Blazei Murill in Inflammatory Bowel Disease (IBD) one ingredient in a multi-herb preparation | Ulcerative Colitis, Crohn's Disease | 100 | Completed | — | 30 ml |
| NCT04821258 | Effect of the Nutraceutical "MICODIGEST 2.0" on the Complications After Surgery for Colorectal Cancer | Colorectal Cancer, Surgery--Complications | 48 | Completed | — | — |
| NCT05192720 | Andosan in Allergic and Asthma Patients one ingredient in a multi-herb preparation | Allergic Asthma, Allergic Rhinoconjunctivitis | 34 | Completed | — | — |
| NCT07195552 | Clinical Trial: Rapid Immune Modulating Effects | Immune Surveillance | 12 | Recruiting | — | — |
| NCT03198455 | Does Medicinal Mushroom Agaricus Blazei Protect Against Allergy and Asthma? one ingredient in a multi-herb preparation | Pollen; Allergy, Asthma | 60 | Completed | — | — |
The compounds the research names
Formula and mass from PubChem. Naming a compound is not a claim that it does anything in a person.
C18H32O16
C28H44O
What it looks like in the field
Research-grade observations, each by a different photographer. Every one links to the record it came from.
In the kitchen
Sweet and almond-like, which is where 'almond mushroom' comes from.
Cooked like any field mushroom, though most of it is sold dried or as an extract rather than eaten fresh.
Where it has been recorded, and when it fruits
575 verified occurrence records with coordinates, from GBIF. This is where people have recorded it, which follows where recorders live as much as where the fungus grows — read the shape, not the ranking.
| United States | 307 | |
| United Kingdom | 48 | |
| Brazil | 29 | |
| Netherlands | 29 | |
| Mexico | 20 | |
| Spain | 19 | |
| Australia | 17 | |
| MQ | 10 | |
| DM | 9 | |
| Sweden | 9 | |
| Argentina | 8 | |
| Colombia | 8 |
Most records fall in Aug. Northern-hemisphere recorders dominate the dataset, so a southern population would not show here.
iNaturalist separately holds 130 research-grade observations of it.
What has been reported going wrong
No voluntary adverse-event report to the US Food and Drug Administration names a product by this name. That is an absence of reports, not a demonstration of safety: these are the products least likely to be reported on, because nobody is required to.
The newest randomised trials and reviews
Indexed in Europe PMC. Titles and journals only — follow the link to read the paper where the publisher allows it.