Updated
Mood and anxiety
Oyster mushroom, lion's mane, reishi and four others have been tried in people for this. The register's own words for this are depression, anxiety, mood.
Fourteen registered trials have looked at this, and not one of them has reported a result.
Species by species
| Species | How far it has got | Trials | With a result | Randomised | Commonly taken for it |
|---|---|---|---|---|---|
| Oyster mushroom Pleurotus ostreatus | Repeated trials | 4 | 0 | 2 | — |
| Lion's mane Hericium erinaceus | Repeated trials | 1 | 0 | 2 | yes |
| Reishi Ganoderma lucidum | Being tested now | 3 | 0 | 0 | — |
| Chaga Inonotus obliquus | Being tested now | 1 | 0 | 0 | — |
| Cordyceps Cordyceps militaris | Being tested now | 1 | 0 | 0 | — |
| Poria Wolfiporia extensa | Being tested now | 1 | 0 | 0 | — |
| Zhu ling Polyporus umbellatus | Being tested now | 1 | 0 | 0 | — |
The trials themselves
Every registered study that names one of these species and a condition the register files under this heading.
| Register | Study | Condition | People | Status | Result posted | Dose in the protocol |
|---|---|---|---|---|---|---|
| NCT04846010 | Recovering Damaged Cells for Sequelae Caused by COVID-19, SARS-CoV-2 | Sequelae of; Infection, Post Infection Glomerulonephritis | 2000 | Unknown | — | — |
| NCT04846010 | Recovering Damaged Cells for Sequelae Caused by COVID-19, SARS-CoV-2 | Sequelae of; Infection, Post Infection Glomerulonephritis | 2000 | Unknown | — | — |
| NCT07524777 | Ganoderma Spores Modulate the Gut-Brain Axis | Depression, Thyroid Cancer | 300 | Completed | — | 4g/day |
| NCT06429514 | Study on the Mechanism of Ganoderma Lucidum Spore Powder in the Treatment of Depression | Depression, Thyroid Cancer | 298 | Completed | — | 2g |
| NCT05508529 | Natural Modulators of Immune Function and Mood one ingredient in a multi-herb preparation | Stress | 120 | Completed | — | — |
| NCT06406946 | Mushrooms, Mood and Mental Wellbeing in Gen Z Women one ingredient in a multi-herb preparation | Well-Being, Psychological, Mood | 84 | Completed | — | 1.8 g, 600mg |
| NCT07407777 | Evaluation of Gut-Related Well-Being and Mood Effects of a Daily Nutritional Food Ingredient From the Co-Ferme | Gastrointestinal Discomfort, Digestive Well Being | 80 | Recruiting | — | — |
| NCT06846827 | Cognitive, Mood, Anti-Inflammatory and Metabolic Effects of Chronic Oyster Mushroom Intervention in Older Adul | Cognitive Change, Mood | 80 | Completed | — | 9.39g, 6.67g |
| NCT07665840 | Effects of L-Theanine and Hericium Erinaceus Gummies on Psychological, Cognitive, and Sleep Quality in Univers | Psychological Stress, Anxiety | 67 | Completed | — | 30 mg, 50 mg |
| NCT05594329 | Neurological, Inflammatory and Metabolic Effects of Acute Mushroom Intervention in Older Adults | Cognitive Change, Mood | 33 | Completed | — | 18.78g, 9.39g |
| NCT07310108 | Evaluation of Cordyceps Militaris M2-116-04 for Its Potential Sport and Exercise Nutrition Applications in Hea | Aerobic, Exercise | 32 | Completed | — | — |
| NCT05900024 | A Study to Evaluate the Effect of Funk It Cycle Bites on PMS | Premenstrual Syndrome | 30 | Completed | — | — |
| NCT04989972 | Assessing the Efficacy of Micro-dosed Psilocybin on Reducing Anxiety & Depression Levels in Adults | Anxiety and Depression | — | Withdrawn | — | 1 mg |
| NCT05252598 | Mood and Cognitive Effects of Psilocybin in Healthy Participants | Mood Disturbance, Mood Change | — | Withdrawn | — | 1mg |
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